Tuo Yang et al. (2021) MalDA, Accelerating Malaria Drug Discovery. Trends in Parasitology. (in press).

Luciana Paradela, Richard J. Wall, Sandra Carvalho, Giulia Chemi, Victoriano Corpas-Lopez, Eoin Moynihan, Davide Bello, Stephen Patterson, Lucia Guther, Alan H. Fairlamb, Michael Ferguson, Fabio Zuccotto, Julio Martin, Ian H. Gilbert and Susan Wyllie. (2021) Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial. Cell Chem. Biol. (in press).

Lauren B. Arendse, Susan Wyllie, Kelly Chibale and Ian H. Gilbert. (2021) Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities. ACS Infect Dis. (in press).


Cyril Fersing et al. (2020) Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties. Eur J Med Chem. 206:112668.

Michael G Thomas et al. (2020) Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity. J Med Chem. 63:9523-9539.

Cyril Fersing et al. (2020) 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi. Eur J Med Chem. 202:112558.

Julian Pedron et al. (2020) New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi. ACS Med Chem Lett.11: 464-472.

Richard J. Wall, Sandra Carvalho, Rachel Milne, Juan A. Bueren-Calabuig, Sonia Moniz, Juan Cantizani-Perez,Lorna MacLean, Albane Kessler, Ignacio Cotillo Torrejon, Lalitha Sastry, Sujatha Manthri, Stephen Patterson,Fabio Zuccotto, Stephen Thompson, Julio Martin, Maria Marco, Timothy J. Miles, Manu De Rycker, Michael G. Thomas, Alan H. Fairlamb, Ian H. Gilbert and Susan Wyllie (2020) The Qi site of cytochrome b is a promiscuous drug target in Trypanosoma cruzi and Leishmania donovani. ACS Infect Dis. 6: 515-528.


Susan WyllieStephen BrandMichael ThomasManu De Rycker et al. (2019) Preclinical candidate for the treatment visceral leishmaniasis acts through proteasome inhibition. PNAS.

Corpas-Lopez, V., Moniz, S., Thomas, M., Wall, R. J., Torrie, L. S., Zander-Dinse, D. Tinti, M., Brand, S., Stojanovski, L., Manthri, S., Hallyburton, I., Zuccotto, F., Wyatt, P. G., De Rycker, M., Horn, D., Ferguson, M. A. J., Clos, J., Read, K. D., Fairlamb, A.H., Gilbert, I. H. and Wyllie, S. (2019) Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani. ACS Infect Dis. 5: 111–122.


Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, E., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H., Valentin, A., Rathelot, P., Verhaeghe, P., Vanelle, P., Azas, N. (2018) Non-genotoxic 3-nitroimidazo[1,2-a]pyridines are NTR1 substrates that display potent in vitro antileishmanial activity. ACS Med Chem Lett. 10: 34-39.

Webster, L. A., Thomas, M., Urbaniak, M., Wyllie, S., Ong, H. B., Tinti, M., Fairlamb, A. H., Boesche, M., Ghidelli-Disse, S., Drewes, G. and Gilbert, I. H. (2018) Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome. ACS Infect Dis. 4: 1475-1486.

Pedron, J., Boudot, C., Bourgeade-Delmas, S. et al. (2018) Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions. ChemMedChem. 13: 2217-2228.

Wall, R.J., Rico, E., Lukac, I., Zuccotto, F., Elg, S., Gilbert, I. H., Freund, Y., Alley, M. R. K., Field, M. C., Wyllie, S. and Horn D. (2018) Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. PNAS 115: 9616-9621.

Fersing, C., Boudot, C., Pedron, J. et al. (2018) 8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type I nitroreductases. Eur J Med Chem. 157:115-126.

Wyllie, S. Thomas, M., Patterson, S. et al. (2018) Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis. Nature 560:192-197.

Pedron, J., Boudot, C., Hutter, S. et al. (2018) Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study. Eur J Med Chem. 155:135-152.

Wall, R. J., Moniz, S., Thomas, M. G., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I. H., Horn, D., Fairlamb, A. H. and Wyllie S. (2018) Anti-trypanosomal 8-hydroxy naphthyridines are chelators of divalent transition metals. Antimicrob Agents Chemother. 62. pii: e00235-18.


Torrie, L. S, Brand, S. Robinson, D. A. et al. (2017) Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani. ACS Infect Dis. 3: 718-727.

Field, M. C., Horn, D., Fairlamb, A. H., Ferguson, M. A. J., Gray, D. W., Read, K. D., De Rycker, M., Torrie, L. S., Wyatt, P. G., Wyllie, S. and Gilbert, I. H. (2016) Antitrypanosomatid drug discovery: An ongoing challenge and a continuing need. Nature Rev. Microbiol. 15, 217-231.


Wyllie, S., Norval, S., Roberts, A. J., Patterson, S., Foth, B. J., Berriman, M., Read, K. D. and Fairlamb, A. H.   (2016) Activation of bicyclic nitro-drugs by a novel nitroreductase (NTR2) in Leishmania. PLoS Pathog. e1005971.